Chinese scientists crack the mysteries of H7N9 bird flu virus infection

Recently learned from the official website of the Chinese Academy of Sciences that the Gao Fu Group of the Beijing Institute of Biological Sciences and the Institute of Microbiology of the Chinese Academy of Sciences has made breakthroughs in the human mechanism of the H7N9 bird flu virus infection. This study not only revealed the mysteries of the H7N9 virus infecting human beings. It provides an important theoretical basis for the study of the possibility of interpersonal transmission of H7N9 virus, and also provides an important basis for the re-evaluation of H7N9 epidemic and the formulation of prevention and control strategies. Related research papers were published online in the journal Science on September 5.

The outbreak of the H7N9 bird flu virus in February this year was a new type of reassortant virus that was first discovered in Shanghai and Anhui. Gao Fu’s team led by the Beijing Institute of Biological Sciences, the Institute of Microbiology, and the China Center for Disease Control and Prevention jointly focused on the two strains that were first reported in this outbreak and explored the mysteries of the H7N9 bird flu virus infection. .

The paper's first author, Shi Yi, an associate researcher at the Beijing Institute of Biological Sciences, Chinese Academy of Sciences, said that the Anhui strain was a pandemic strain in the influenza outbreak, while the Shanghai strain was only isolated in one case and the two strains were at a level The sequences show their uniqueness. The study found that the Anhui strain binds both avian and human receptors, whereas the Shanghai strain preferentially binds to avian-derived receptors. Due to the ability to obtain human receptor binding, Anhui strain has the possibility of widespread prevalence among people.

Shi Yi said that currently scientists believe that the H7N9 bird flu virus has limited human-to-human transmission capabilities. The researchers speculate that because the H7N9 virus still has the ability to strongly bind to avian receptors, there are many mucin bindings with avian receptors in the human respiratory tract. Lived the spread of the virus, making the H7N9 virus unable to effectively spread. Li Lanjuan, director of the State Key Laboratory of Infectious Diseases Diagnosis and Treatment at the First Affiliated Hospital of Zhejiang University School of Medicine and an academician of the Chinese Academy of Engineering, said that the findings fully explained the epidemic characteristics of the H7N9 strain in this influenza outbreak.

Researchers believe that we must pay close attention to the mutation of the H7N9 virus and do a good job of monitoring and detection. Because some mutant viruses lose the ability to strongly bind to avian-derived receptors and continue to retain the binding capacity of human receptors, they may trigger influenza pandemics. .


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